Screening of Natural Compounds as Matrix Metalloproteinase and Aldose Reductase Inhibitors: Drug Design for Diabetic Retinopathy

Diabetic retinopathy (DR) is a micro-vascular complication of diabetes and one of the leading causes of blindness. Two of the possible candidate PROTEINS contributing to the development of diabetic retinopathy are aldose reductase (AR) and Matrix metalloproteinase-2 (MMP2). In the current study plant derived medicinal compounds and chemical compounds are studied by Docking analysis that are carried out using Maestro (10.2) (Schrodinger suite).The screened compounds were found to possess good binding affinity with these proteins and hence are considered diabetic retinopathy inhibitors. In this study, Calebin, Isolated from curcuminoid Plant of turmeric (Curcuma longa) was found to have high Binding Affinity and was proved to be the naturally available novel inhibitor of Aldose reductase. Acarbose was found to have high Binding Affinity to the Matrix metalloproteinase-2 drug target.From this study it is concluded that these natural compounds were found to have good binding affinity with these target proteins and considered to be effective drug targets for treatment of diabetic retinopathy (DR).